• Cell line development is a critical step in the process of generating biopharmaceutical molecules, such as monoclonal antibodies. The process often begins with transfecting the host cell type with the DNA encoding the therapeutic protein of interest allowing for random or directed integration of target DNA into the host cell genome. Thousands of clones are screened to isolate the rare high producing cells, a manual and time-consuming process.

    Learn More   

  • Cell line development requires the discovery of single cell-derived clones that produce high and consistent levels of the target therapeutic protein. A critical first step in the process is the isolation of single, viable cells. Single cells proliferate to form colonies that can then be assessed for productivity of the target therapeutic protein. Viability and growth rates of single cell-derived clones can be characterized on the CloneSelect Imager and the SpectraMax i3x microplate reader and imaging cytometer.

  • The soft agar colony formation assay is a classical and renowned technique for characterizing the ability of cells to undergo anchorage-independent growth, a hallmark of carcinogenesis. After seeding in a matrix that enhances colony formation, such as a semi-solid media, cells are typically incubated with compounds that may affect colony growth. The CloneSelect Imager can image every well and automatically calculate confluence, estimate colony number and area, and track colony growth.

    Read More   

  • Wound healing assays are used in a range of disciplines to study cell migration, the coordinated movement of a cell population. A manual or standardized wound is generated on a monolayer of cells grown in microplates. The microplates can be screened against a library to study the effect on cell migration. The effect of a library of compounds or genes can be studied using this approach. The CloneSelect Imager enables the rapid imaging (90 s per plate) and objective, automated analysis of cell migration.

    Read Application Note   

  • Monoclonal antibodies (mAbs) originate from one unique parent cell, thus binding only to a single epitope. Monoclonal antibody discovery typically refers to the screening and identification of specific antibodies that target a specific epitope for the diagnosis and treatment of diseases, like the coronavirus for COVID-19.

    Learn More   

  • Cell line development and assurance of monoclonality are critical steps in the process of generating biopharmaceutical molecules, such as monoclonal antibodies. A cell line can be established following the isolation of a single viable cell robustly expressing the protein of interest. A key milestone in this process is documenting evidence of clonality. Documentation of clonality is typically image-based, whereby an image of a single cell is produced and included in regulatory filings.

今日はどんなお手伝いをしましょうか?

当社の高い能力を有するチームが、お客様とともに最前線に立ち、遠隔でまたは現場での製品デモンストレーション、
ウェビナーなどを実施し、困難な研究上の課題の解決をお手伝いします。今日はどんなお手伝いをしましょうか?

CloneSelect Imagerの仕様とオプション

CloneSelect Imager

CloneSelect Imager FL

画像取得

ソフトウェア Windows 10 搭載の高性能なコンピューターにプリインストールされた専用の画像取得・解析ソフトウェア Windows 10 搭載の高性能なコンピューターにプリインストールされた専用の画像取得・解析ソフトウェア
光源 明視野:白色透過光
光源:キセノンフラッシュランプ(5 W)
明視野:白色透過光
光源:キセノンフラッシュランプ(5 W)
蛍光:2 チャンネル(GFP、RFP)
光源:LED
カメラ 高解像度CMOSカメラ 高解像度CMOSカメラ
画像取得速度 90 秒(96 ウェルプレート) 明視野:2 分以内(96/384 ウェルプレート)
蛍光:8 分以内(96/384 ウェルプレート)
対物レンズ 4x 4x
解像度 標準:3.6 μm 高解像度:1.8 μm
標準:3.6 μm

ハードウェア

プレート互換性 SBS 準拠の6、12、24、96、384ウェルプレート SBS 準拠の96、384 ウェルプレート
プレート枚数 1枚 1枚
寸法(幅×奥行×高) 57.4 cm × 72.4 cm × 45.4 cm(本体) 57.4 cm × 72.4 cm × 45.4 cm(本体)
12.5 cm × 26.3 cm × 16.3 cm(外部光源)
重量 45 kg(本体) 45 kg(本体)
3.6 kg(外部光源)

規制準拠

コンプライアンス CE CE
品質 ISO9001:2008 certified ISO9001:2008 certified

自動化の互換性
ロボットインテグレーションのためのAPI が利用可能(詳細はお問い合わせください)

今日はどんなお手伝いをしましょうか?

当社の高い能力を有するチームが、お客様とともに最前線に立ち、遠隔でまたは現場での製品デモンストレーション、
ウェビナーなどを実施し、困難な研究上の課題の解決をお手伝いします。今日はどんなお手伝いをしましょうか?

CloneSelect Imagerのリソース

  • Brochure

    CloneSelect Imager

    蛍光および明視野での高速な画像取得とモノクローナリティレポートの作成機能を含むインテリジェントな画像解析を実装するシステム

    Brochureをダウンロードする 

  • すべて表示
  • アプリケーションノート
  • Blog
  • Brochure
  • eBook
  • Flyer
  • Presentations
  • Scientific Poster
  • 動画とウェビナー
  • Blog

    COVID-19 Timeline: Diagnostics, Vaccines, and Therapeutic Antibody Development

    Global research efforts are focused on understanding the SARS-CoV-2 virus in order to develop potential therapies for COVID-19. Join us as we explore a scientific timeline of key…

    ブログを読む 

  • Blog

    Life sciences technology predictions for 2021

    For over 30 years, Molecular Devices has been at the forefront of technological advances which have contributed to significant scientific breakthroughs. To kick off the new year, we…

    ブログを読む 

  • eBook

    Tips from the cell line development front

    Download the eBook, which features articles on monoclonality assurance, screening of stable cell lines, and tips on improving cell line productivity.

    eBookをダウンロードする 

  • Brochure

    CloneSelect Imager Monoclonality Report Feature

    Providing image evidence of monoclonality in the cell line development process is not as simple as exporting an image of a single cell. For example, high-resolution images of the ent…

    Brochureをダウンロードする 

  • Brochure

    Accelerate Cell Line Development

    Explore PDF to learn how you can accelerate your cell line development and get to your high value hits faster.

    Brochureをダウンロードする 

  • Blog

    How to Develop Monoclonal Cell Lines for Stem Cell Engineering

    Monoclonal assurance is undeniably critical in cell line development for generating therapeutics, such as monoclonal antibodies or cell-based therapies. To utilize a cell line for…

    ブログを読む 

  • Blog

    Accelerated Production of Monoclonal Antibodies for the Treatment of SARS-CoV-2

    With solutions from Molecular Devices, scientists can fast-track the FDA approval process and accelerate monoclonal antibody discovery The timeline to identify and develop…

    ブログを読む 

  • Brochure

    Clone screening solutions

    Advance your microbial and mammalian clone screening with proven, automated technologies

    Brochureをダウンロードする 

  • アプリケーションノート

    Direct screening cytotoxic and antiproliferative activities of drug compounds on human leukemia U937 cell

    A fast, reliable and cost-effective high-throughput screening method for antiproliferation and toxicology evaluation in the early stage of drug discovery is highly attractive. The…

    アプリケーションノートをダウンロードする 

  • Blog

    The evolution of CHO cells’ role in cell line development

    Since the first approval of recombinant insulin and human growth hormone in the early 1980s, a multitude of recombinant protein therapeutics have been approved by regulatory…

    ブログを読む 

  • High assurance monoclonality for cell line development

    Double confirmation of clonality. Image based evidence confirming single cell deposition event, and single cell in 96- and 384-well plate post sort

    Flyerをダウンロードする 

  • Blog

    Get to know our Field Applications Scientist: Dwayne Carter

    Dwayne Carter gives us a taste of 3D bioprinting, clone screening, and Caribbean cuisine Dwayne Carter is a cell biologist and educator who joined Molecular Devices in November 2020…

    ブログを読む 

  • eBook

    Accelerate vaccine development

    Immunology is now, more than anytime in recent history, one of the top fields of research. Monoclonal antibodies (mAbs) continue to enjoy intense interest as potential therapeutics.…

    eBookをダウンロードする 

  • eBook

    Optimize your high-value cell lines

    During the last decade, production of monoclonal antibodies (mAbs) and recombinant proteins using mammalian cells has led to a boom in the introduction of biotherapeutic proteins to…

    eBookをダウンロードする 

  • アプリケーションノート

    A workflow combining single-cell isolation and microplate imaging improves cloning efficiency with higher assurance of clonality

    The isolation of single cells has a broad spectrum of applications, from single-cell genomics to antibody discovery and cell line development.

    アプリケーションノートを読む 

  • アプリケーションノート

    The diverse utility of CloneSelect Imager in label-free imaging applications

    A variety of label-free imaging applications using the CloneSelect Imager, such as colony formation assays and clonality assessment, are presented.

    アプリケーションノートを読む 

  • アプリケーションノート

    Improved productivity of cell line development using fully integrated automated solutions: a series of case studies with the CloneSelect Imager

    Cell line development requires screening tens of thousands of clones in order to find the few clones that are stable, grow well, and produce high yields of bioproduct. In addition to…

    アプリケーションノートを読む 

  • アプリケーションノート

    Confident assurance of clonality using calcein AM with minimal effect on viability

    The development of cell lines that express a specified protein of interest is critical to the generation of biopharmaceutical molecules such as monoclonal antibodies. To establish a…

    アプリケーションノートを読む 

  • Presentations

    Developing High Throughput Mammalian Expression Platforms

    Download PDF and explore more about high throughput mammalian expression platforms & challenges with mammalian systems.

    Presentationsをダウンロードする 

  • Scientific Poster

    Accelerated one-step screening and selection of PER.C6® clones using ClonePix technology

    In this poster, we present data demonstrating that CloneMedia-PER.C6 supports the growth of cells into discrete colonies that can be imaged, ranked and picked using the ClonePix plat…

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Rapid High-Throughput Screening and Selection for Clonal Populations of Therapeutic Protein/Antibody Producer Cells and Reporter Cell-Lines, Using Fluorescence Cell Based Assay Techniques

    This PDF file explores ClonePix FL Technology which is based on the culture of mammalian cell lines in semisolid media originating from one single parent cell.

    Scientific Posterをダウンロードする 

  • Scientific Poster

    High Throughput Screening and Selection of Clonal Populations of Reporter Cell Lines, using Fluorescence Cell Based Assay Techniques

    Advances in cell culture techniques are facilitating development of novel screening assays which enable drug discovery programmes to rely on cell-based assays for high-throughput scr…

    Scientific Posterをダウンロードする 

  • アプリケーションノート

    Objective quantification of cell migration on the CloneSelect Imager System

    Cell migration is a key process in normal development, immune function and wound healing. Abnormal cell migration is a feature of conditions such as cardiovascular disease and cancer.…

    アプリケーションノートを読む 

  • Scientific Poster

    Bypassing the Need for High Throughput Processing in Cell Line Development: Rapid, Selective in Situ Cell Screening by Phosphopeptide Recognition

    Animal cell culture technology has been thrust to the forefront of the biopharmaceutical industry because of the superior fidelity of mammalian cells in producing clinically relevant…

    Scientific Posterをダウンロードする 

  • Brochure

    Reagents and Supplies

    Molecular Devices offer products and unrivaled solutions that utilize imaging & intelligent image analysis to support basic research, pharmaceutical & biotherapeutic developm…

    Brochureをダウンロードする 

  • Scientific Poster

    Rapid Selective in Situ Screening of Hybridomas in Semi-Solid Medium

    Explore a simple one-step hybridoma selective secretion assay for detecting and isolating antigen-specific, IgG-secreting hybridoma clones in as little as 8 days from fusion with min…

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Integration of Automated Colony Picking into Fast Track Cell Line Development Process

    Download this PDF to learn about fast track cell Line development process with integrated automated colony picker.

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Rapid Development of a Serum-Free, Suspension-Adapted CHO Cell Production Process

    Download PDF to explore the process for developing serum-free CHO cell line.

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Imaging, Screening and Automated Selection of Mouse Embryonic Stem Cells

    Explore non-invasive method for mouse Embrionic Stem Cell culture colony number & growth rate monitoring and identification using specific probes.

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Non-Invasive, Label-Free Analysis of Cell Migration using CloneSelect™ Imager

    Explore CloneSelect Imager’s Migration that provides a simple, but quantitative & accurate measure of cell migration based on objective, sensitive label-free cell detection.

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Rapid Monoclonality Verification Methods to Boost Cell Line Development

    Here we present a fluorescent method for identifying monoclonal CHO-S cells using CellTracker Green CMDFA.

    Scientific Posterをダウンロードする 

  • アプリケーションノート

    Confluence and growth curve generation on the CloneSelect Imager

    The ability to monitor cell proliferation has become increasingly important, particularly with the widespread use of in vitro cell lines as model systems. Proliferation rates can be…

    アプリケーションノートを読む 

  • アプリケーションノート

    Enhanced development of virus-specific hybridomas using ClonePix and CloneSelect Imager Technologies

    The ClonePix System was employed in the high-throughput screening of hundreds of sub-cloned colonies from parental hybridoma material (historically parental line yields were less than…

    アプリケーションノートを読む 

  • Monoclonality Assurance Using CloneSelect Single-Cell Printer and CloneSelect Imager in Human Stem Cell (hSC) Engineering Workflow – AstraZeneca

  • Monoclonality Workflow

  • Stable Cell Line Development Workflow

  • Hybridoma Workflow

  • The many and varied workflows of cell line development

  • Optimized workflow for rapid identification of neutralizing antibodies against viral particles

  • CloneSelect Imager

  • Identification and Selection of GPCR Cell Lines with ClonePix 2

  • アプリケーションノート

    Direct screening cytotoxic and antiproliferative activities of drug compounds on human leukemia U937 cell

    A fast, reliable and cost-effective high-throughput screening method for antiproliferation and toxicology evaluation in the early stage of drug discovery is highly attractive. The…

    アプリケーションノートをダウンロードする 

  • アプリケーションノート

    A workflow combining single-cell isolation and microplate imaging improves cloning efficiency with higher assurance of clonality

    The isolation of single cells has a broad spectrum of applications, from single-cell genomics to antibody discovery and cell line development.

    アプリケーションノートを読む 

  • アプリケーションノート

    The diverse utility of CloneSelect Imager in label-free imaging applications

    A variety of label-free imaging applications using the CloneSelect Imager, such as colony formation assays and clonality assessment, are presented.

    アプリケーションノートを読む 

  • アプリケーションノート

    Improved productivity of cell line development using fully integrated automated solutions: a series of case studies with the CloneSelect Imager

    Cell line development requires screening tens of thousands of clones in order to find the few clones that are stable, grow well, and produce high yields of bioproduct. In addition to…

    アプリケーションノートを読む 

  • アプリケーションノート

    Confident assurance of clonality using calcein AM with minimal effect on viability

    The development of cell lines that express a specified protein of interest is critical to the generation of biopharmaceutical molecules such as monoclonal antibodies. To establish a…

    アプリケーションノートを読む 

  • アプリケーションノート

    Objective quantification of cell migration on the CloneSelect Imager System

    Cell migration is a key process in normal development, immune function and wound healing. Abnormal cell migration is a feature of conditions such as cardiovascular disease and cancer.…

    アプリケーションノートを読む 

  • アプリケーションノート

    Confluence and growth curve generation on the CloneSelect Imager

    The ability to monitor cell proliferation has become increasingly important, particularly with the widespread use of in vitro cell lines as model systems. Proliferation rates can be…

    アプリケーションノートを読む 

  • アプリケーションノート

    Enhanced development of virus-specific hybridomas using ClonePix and CloneSelect Imager Technologies

    The ClonePix System was employed in the high-throughput screening of hundreds of sub-cloned colonies from parental hybridoma material (historically parental line yields were less than…

    アプリケーションノートを読む 

  • Blog

    COVID-19 Timeline: Diagnostics, Vaccines, and Therapeutic Antibody Development

    Global research efforts are focused on understanding the SARS-CoV-2 virus in order to develop potential therapies for COVID-19. Join us as we explore a scientific timeline of key…

    ブログを読む 

  • Blog

    Life sciences technology predictions for 2021

    For over 30 years, Molecular Devices has been at the forefront of technological advances which have contributed to significant scientific breakthroughs. To kick off the new year, we…

    ブログを読む 

  • Blog

    How to Develop Monoclonal Cell Lines for Stem Cell Engineering

    Monoclonal assurance is undeniably critical in cell line development for generating therapeutics, such as monoclonal antibodies or cell-based therapies. To utilize a cell line for…

    ブログを読む 

  • Blog

    Accelerated Production of Monoclonal Antibodies for the Treatment of SARS-CoV-2

    With solutions from Molecular Devices, scientists can fast-track the FDA approval process and accelerate monoclonal antibody discovery The timeline to identify and develop…

    ブログを読む 

  • Blog

    The evolution of CHO cells’ role in cell line development

    Since the first approval of recombinant insulin and human growth hormone in the early 1980s, a multitude of recombinant protein therapeutics have been approved by regulatory…

    ブログを読む 

  • Blog

    Get to know our Field Applications Scientist: Dwayne Carter

    Dwayne Carter gives us a taste of 3D bioprinting, clone screening, and Caribbean cuisine Dwayne Carter is a cell biologist and educator who joined Molecular Devices in November 2020…

    ブログを読む 

  • Brochure

    CloneSelect Imager Monoclonality Report Feature

    Providing image evidence of monoclonality in the cell line development process is not as simple as exporting an image of a single cell. For example, high-resolution images of the ent…

    Brochureをダウンロードする 

  • Brochure

    Accelerate Cell Line Development

    Explore PDF to learn how you can accelerate your cell line development and get to your high value hits faster.

    Brochureをダウンロードする 

  • Brochure

    Clone screening solutions

    Advance your microbial and mammalian clone screening with proven, automated technologies

    Brochureをダウンロードする 

  • Brochure

    Reagents and Supplies

    Molecular Devices offer products and unrivaled solutions that utilize imaging & intelligent image analysis to support basic research, pharmaceutical & biotherapeutic developm…

    Brochureをダウンロードする 

  • eBook

    Tips from the cell line development front

    Download the eBook, which features articles on monoclonality assurance, screening of stable cell lines, and tips on improving cell line productivity.

    eBookをダウンロードする 

  • eBook

    Accelerate vaccine development

    Immunology is now, more than anytime in recent history, one of the top fields of research. Monoclonal antibodies (mAbs) continue to enjoy intense interest as potential therapeutics.…

    eBookをダウンロードする 

  • eBook

    Optimize your high-value cell lines

    During the last decade, production of monoclonal antibodies (mAbs) and recombinant proteins using mammalian cells has led to a boom in the introduction of biotherapeutic proteins to…

    eBookをダウンロードする 

  • High assurance monoclonality for cell line development

    Double confirmation of clonality. Image based evidence confirming single cell deposition event, and single cell in 96- and 384-well plate post sort

    Flyerをダウンロードする 

  • Presentations

    Developing High Throughput Mammalian Expression Platforms

    Download PDF and explore more about high throughput mammalian expression platforms & challenges with mammalian systems.

    Presentationsをダウンロードする 

  • Scientific Poster

    Accelerated one-step screening and selection of PER.C6® clones using ClonePix technology

    In this poster, we present data demonstrating that CloneMedia-PER.C6 supports the growth of cells into discrete colonies that can be imaged, ranked and picked using the ClonePix plat…

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Rapid High-Throughput Screening and Selection for Clonal Populations of Therapeutic Protein/Antibody Producer Cells and Reporter Cell-Lines, Using Fluorescence Cell Based Assay Techniques

    This PDF file explores ClonePix FL Technology which is based on the culture of mammalian cell lines in semisolid media originating from one single parent cell.

    Scientific Posterをダウンロードする 

  • Scientific Poster

    High Throughput Screening and Selection of Clonal Populations of Reporter Cell Lines, using Fluorescence Cell Based Assay Techniques

    Advances in cell culture techniques are facilitating development of novel screening assays which enable drug discovery programmes to rely on cell-based assays for high-throughput scr…

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Bypassing the Need for High Throughput Processing in Cell Line Development: Rapid, Selective in Situ Cell Screening by Phosphopeptide Recognition

    Animal cell culture technology has been thrust to the forefront of the biopharmaceutical industry because of the superior fidelity of mammalian cells in producing clinically relevant…

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Rapid Selective in Situ Screening of Hybridomas in Semi-Solid Medium

    Explore a simple one-step hybridoma selective secretion assay for detecting and isolating antigen-specific, IgG-secreting hybridoma clones in as little as 8 days from fusion with min…

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Integration of Automated Colony Picking into Fast Track Cell Line Development Process

    Download this PDF to learn about fast track cell Line development process with integrated automated colony picker.

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Rapid Development of a Serum-Free, Suspension-Adapted CHO Cell Production Process

    Download PDF to explore the process for developing serum-free CHO cell line.

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Imaging, Screening and Automated Selection of Mouse Embryonic Stem Cells

    Explore non-invasive method for mouse Embrionic Stem Cell culture colony number & growth rate monitoring and identification using specific probes.

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Non-Invasive, Label-Free Analysis of Cell Migration using CloneSelect™ Imager

    Explore CloneSelect Imager’s Migration that provides a simple, but quantitative & accurate measure of cell migration based on objective, sensitive label-free cell detection.

    Scientific Posterをダウンロードする 

  • Scientific Poster

    Rapid Monoclonality Verification Methods to Boost Cell Line Development

    Here we present a fluorescent method for identifying monoclonal CHO-S cells using CellTracker Green CMDFA.

    Scientific Posterをダウンロードする 

  • Monoclonality Assurance Using CloneSelect Single-Cell Printer and CloneSelect Imager in Human Stem Cell (hSC) Engineering Workflow – AstraZeneca

  • Monoclonality Workflow

  • Stable Cell Line Development Workflow

  • Hybridoma Workflow

  • The many and varied workflows of cell line development

  • Optimized workflow for rapid identification of neutralizing antibodies against viral particles

  • CloneSelect Imager

  • Identification and Selection of GPCR Cell Lines with ClonePix 2

今日はどんなお手伝いをしましょうか?

当社の高い能力を有するチームが、お客様とともに最前線に立ち、遠隔でまたは現場での製品デモンストレーション、
ウェビナーなどを実施し、困難な研究上の課題の解決をお手伝いします。今日はどんなお手伝いをしましょうか?