Neuro-Sys in Gardanne, France, is a private contract research organization (CRO) and drug discovery company which mainly focuses on neurodegenerative diseases, particularly Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis (ALS) diseases.
The Neuro-Sys Research & Development laboratory develops innovative extracts and compounds derived from medicinal plants with a neuroprotective effect on neurodegenerative diseases. To achieve this particular challenge, researchers have set-up specific and powerful in vitro models and fully automated efficacy and mode of action pharmacological platforms. These platforms are also outsourced to scientists working in industry and biotech as a service for efficacy and mode of action purposes.
An ImageXpress® Micro System is embedded into the group’s automated efficacy platform and scientists are using this system to analyze neuronal primary cell cultures. Yann Jaudouin, CEO of Neuro-Sys, explains “Typical studies involve cell survival, neurite networks, protein overlaps (synapsis, caspase 3 evaluation, Tau phosphorylation…), neuromuscular junctions, myelination kinetics and glial cell proliferation. All of these experiments are performed in a medium-throughput fashion”.
Below are examples of images that researchers at Neuro-Sys have acquired using the ImageXpress® Micro System
Figure 1: Caspase 3 TH Overlap
Figure 2: Cortical neurons
Figure 3: Cortical neurons astrocytes
Figure 4: Neuromuscular junction
Figure 5: Overlap myeline neurite
Find out more about Neuro-Sys
ImageXpress Micro XLS High-Content Analysis System